Imuran belongs to a group of medicines called immunosuppressants .
These drugs decrease the strength of the body’s protection and defense system, which is necessary when the body defends itself from aggressors in an excessive, inappropriate or undesirable manner. In other words as an immunosuppressant, Imuran is indicated to help the body to face some diseases called autoimmune, in which the organism reacts against itself, starting to attack and harm the organs themselves.
It is also used in the case of organ transplants (for example, kidney, heart or liver ), to prevent rejection of the transplanted organ.
Some of the autoimmune diseases are:
- Severe rheumatoid arthritis ;
- Systemic lupus erythematosus ;
- Dermatomyositis / polymyositis;
- Chronic autoimmune active hepatitis ;
- Pemphigus vulgaris;
- Polyarteritis nodosa;
- Anemia autoimmune hemolytic;
- Purple chronic refractory idiopathic thrombocytopenic.
Your doctor has chosen this medication to suit you and your condition. Imuran can be used alone, as a single therapy, but it is most often prescribed in combination with other medicines.
How does Imuran work?
The active substance in Imuran is azathioprine , a derivative of mercaptopurine . The mechanisms by which this substance acts, reducing the body’s defense reactions and the strength of the immune system (of protection), have not yet been clarified with precision. The therapeutic effect of Imuran may become evident only after weeks or months of treatment.
What are the contraindications for Imuran?
Imuran is not indicated for patients who have known sensitivity to azathioprine or any other component of the drug. It is more likely that patients who are sensitive to mercaptopurine will also be sensitive to Imuran.
Pregnancy and lactation:
Imuran should not be given to patients who are pregnant or intend to become pregnant, unless the benefits assessed by the doctor outweigh the risks to the fetus. As with all chemotherapy drugs, the woman must take appropriate measures to avoid pregnancy during treatment (her or her partner’s) with Imuran.
Mercaptopurine, a substance present in Imuran’s formula, has been identified in breast milk.
Category D of pregnancy risk.
This medicine should not be used by pregnant women without medical advice. Inform your doctor immediately if you suspect a pregnancy.
Immunosuppressive drugs can activate primary foci of tuberculosis .
Physicians who monitor patients undergoing immunosuppression should be alert to the possibility of the appearance of an active disease, thus taking all precautions for early diagnosis and treatment.